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Scientists based at Neuroscience Research Australia (NeuRA) studied patients diagnosed with CBS and found that they show profound deficits in recognising emotions, such as distinguishing a frown from a grimace, or a look of shock, as well as difficulty understanding how other people are feeling.
Senior author of the study, Associate Professor Olivier Piguet (pictured), who is also a past Alzheimer's Australia Dementia Research Foundation grant recipient said,
“Despite its pathological overlap with frontotemporal dementia, emotion processing in corticobasal syndrome hasn’t been systematically explored before. This study sheds light on the disease and gives us a greater understanding of how emotion is processed in the brain.”
“Corticobasal syndrome typically presents as a motor disturbance. Behaviour and cognitive changes tend to be ignored given the prominence of physical symptoms such as alien limb syndrome.”
This study reveals, for the first time, profound emotional impairments in CBS which are more severe than those seen in Alzheimer’s disease, the most common form of dementia. The severity of these emotion processing deficits were associated with atrophy in the basal ganglia, a structure deep within the brain, which is also involved in motivation and motor control.
Disturbed emotion processing and difficulty with social interactions have been previously reported in other dementias, and have a significant impact on day-to-day life. They are characteristic of frontotemporal dementia, and less so of Alzheimer’s disease, reflecting their different patterns of brain neurodegeneration across dementias.
First author of the study, Dr Fiona Kumfor, says,
“Although there is no treatment for CBS, therapy does help to manage symptoms. The results of our study will help CBS patients and families better understand their condition, particularly how it affects mood and behaviour.”
You can listen to an interview with Associate Professor Olivier Piguet here with Neura Science Communicator Siobhan Moylan - listen here.
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